Supporting Information Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
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چکیده
1. Detailed criteria for priming and tolerance in the Metropolis searching algorithm. 2. Two-stage Metropolis search for parameter sets that exhibit priming or tolerance. 3. Statistical method used to identify backbone motifs. 4. Motif density is more robust than frequency to variation in the topological cut-off. 5. 2D parameter correlations demonstrate how parameter compensation affects topological robustness.
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Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
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